Asian Journal of Research in Medicine and Medical Science

Childhood immunisation is a key public health intervention, yet its acceptability among caregivers may be shaped by maternal knowledge, socio-demographic conditions, cultural beliefs and healthcare system factors. This study investigated the determinants of childhood immunisation response among mothers attending primary healthcare centres in Udi and Awgu Local Government Areas of Enugu State, Nigeria. A descriptive cross-sectional survey design was adopted. The study involved 333 mothers of children aged 0–23 months attending selected primary healthcare centres. Data were collected using a researcher-developed, interviewer-administered questionnaire and analysed using descriptive statistics, chi-square tests and binary logistic regression at a 5% level of significance. The findings showed that 70.0% of respondents had good knowledge of childhood immunisation schedules. A significant relationship was observed between maternal knowledge of immunisation schedules and childhood immunisation response (p = .031). Socio-demographic characteristics were also significantly related to immunisation response (p < .001), with maternal age and marital status identified as significant predictors. Increasing maternal age reduced the odds of good immunisation response (AOR = .919, 95% CI = .885–.954), and single mothers had lower odds of good response than married mothers (AOR = .262, 95% CI = .133–.515). The study concludes that maternal knowledge and selected socio-demographic characteristics influence childhood immunisation response. Strengthened maternal education, reliable vaccine availability and culturally sensitive counselling may improve childhood immunisation acceptability in the study setting.